Mark Rabinovich was Born in 1870 in the town of Zdvyzhensk (Kiev province of the Russian Empire; now Brusilov, Ukraine). He studied music under the guidance of his grandfather, the klezmer violinist and composer Israel-Moishe Rabinovich.
In 1937-1938 he was the head of the State Ensemble of Jewish Folk Music of the Ukrainian SSR. The ensemble performed on the radio and toured Ukraine and Belarus, Moldova, and Crimea.
Mark Isakovich Rabinovich died in Kiev in 1940.